In order to delete an entity in Drupal we can use entity storage to load an entity and then call "delete" method for it.

// Delete a node.
$node = \Drupal::entityTypeManager()->getStorage('node')->load(1);
if (!empty($node)) {
   $node->delete();
}

Or we can load an entity using static method "load" and then remove it.

// Delete a node.
$node = Node::load(1);
if (!empty($node)) {
   $node->delete();
}

Delete multiple nodes in one operation.

\Drupal::entityTypeManager()->getStorage('node')->delete([
   $nid1 => $node1,
   $nid2 => $node2,
]);